Bayan lalacewa mai tsanani ko na yau da kullum ga shinge na epidermal, tsarin gyaran fata ba tare da bata lokaci ba zai hanzarta samar da keratinocytes, rage lokacin maye gurbin sel epidermal, da daidaitawa da samarwa da sakin cytokines, wanda zai haifar da hyperkeratosis da kumburi mai laushi na fata. . Wannan kuma shine yanayin bayyanar bushewar fata.
Har ila yau, kumburi na gida na iya kara tsananta bushewar fata, a gaskiya ma, rushewar shinge na epidermal yana inganta haɓakawa da kuma saki jerin nau'in cytokines masu kumburi, irin su IL-1he TNF, don haka an lalatar da ƙwayoyin rigakafi na phagocytic, musamman neutrophils. Bayan an jawo hankalinsu zuwa wurin busassun, bayan sun isa wurin da ake nufi, neutrophils suna ɓoye leukocyte elastase, cathepsin G, protease 3, da collagenase a cikin ƙwayoyin da ke kewaye da su, kuma suna samar da furotin a cikin keratinocytes. Matsalolin da ke haifar da wuce kima na aikin protease: 1. Lalacewar salula; 2. Sakin cytokines masu kumburi; 3. Ragewar da ba a kai ba na lambobin sadarwa na cell-to-cell waɗanda ke haɓaka mitosis cell. Ayyukan enzyme na proteolytic a cikin busassun fata, wanda kuma zai iya rinjayar jijiyoyi masu hankali a cikin epidermis, yana hade da pruritus da zafi. Aikace-aikace na saman tranexamic acid da α1-antitrypsin (mai hana protease) zuwa xerosis yana da tasiri, yana nuna cewa xeroderma yana da alaƙa da aikin enzyme na proteolytic.
Dry epidermis yana nufin cewashingen fata yana damuwa, lipids sun ɓace, sunadaran sunadaran sun ragu, kuma an saki abubuwan kumburi na gida.Rashin bushewar fata sakamakon lalacewar shingeya bambanta da bushewa da ke haifar da raguwar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta sau da yawa ya kasa cika tsammanin. Kayan shafawa da aka ƙera don lalacewar shinge ya kamata ba kawai ƙarin abubuwan da ke da alaƙa da stratum corneum ba, irin su ceramides, abubuwan da ke da laushi na halitta, da dai sauransu, amma kuma la'akari da tasirin antioxidant, anti-inflammatory, da anti-cell division, don haka rage bambance-bambancen da bai cika ba. na keratinocytes. Shamaki bushewar fata sau da yawa yana tare da pruritus, kuma ya kamata a yi la'akari da ƙarin kayan aikin antipruritic.
Lokacin aikawa: Juni-10-2022
