Busasshen epidermis yana nufin cewa shingen fata ya lalace, lipids sun ɓace, sunadaran sun ragu

Bayan lalacewa mai tsanani ko na yau da kullun ga shingen epidermal, hanyar gyara fata ta bazata za ta hanzarta samar da keratinocytes, ta rage lokacin maye gurbin ƙwayoyin epidermal, sannan ta daidaita samarwa da sakin cytokines, wanda ke haifar da hyperkeratosis da kumburi mai sauƙi na fata. Wannan kuma al'ada ce ta busasshiyar fata.

Kumburi na gida kuma na iya ƙara ta'azzara bushewar fata, a zahiri, rugujewar shingen epidermal yana haɓaka haɗakar da sakin jerin cytokines masu hana kumburi, kamar IL-1he TNF, ta yadda ƙwayoyin rigakafi na phagocytic, musamman neutrophils, za su lalace. Bayan an jawo su zuwa wurin bushewar, bayan isa inda ake so, neutrophils suna fitar da leukocyte elastase, cathepsin G, protease 3, da collagenase cikin kyallen da ke kewaye, kuma suna samar da kuma wadatar da protease a cikin keratinocytes. Sakamakon da zai iya faruwa sakamakon yawan aikin protease: 1. Lalacewar ƙwayoyin halitta; 2. Sakin cytokines masu hana kumburi; 3. Lalacewar hulɗar ƙwayoyin halitta da ƙwayoyin halitta da wuri wanda ke haɓaka mitosis na ƙwayoyin halitta. Ayyukan enzyme na proteolytic a cikin busasshiyar fata, wanda kuma zai iya shafar jijiyoyin jijiyoyi a cikin epidermis, yana da alaƙa da kuraje da zafi. Shafa tranexamic acid da α1-antitrypsin (mai hana protease) a saman fata yana da tasiri, yana nuna cewa xeroderma yana da alaƙa da aikin enzyme na proteolytic.

Dry epidermis yana nufin cewashingen fata ya dame, lipids sun ɓace, sunadaran sun ragu, kuma abubuwan kumburi na gida suna fitowa.Busasshen fata wanda lalacewar shinge ke haifarwaya bambanta da bushewar fata da raguwar fitar da sinadarin sebum ke haifarwa, kuma tasirin ƙarin lipids mai sauƙi sau da yawa ba ya cika tsammanin. Ya kamata a ƙara danshi a cikin kayan kwalliyar da aka haɓaka don lalacewar shinge ba wai kawai ya ƙara abubuwan da ke haifar da danshi na stratum corneum ba, kamar su ceramides, abubuwan da ke haifar da danshi na halitta, da sauransu, amma kuma a yi la'akari da tasirin antioxidant, anti-inflammatory, da anti-cell division, ta haka ne za a rage rashin cikakken bambance-bambancen keratinocytes. Busasshen fata sau da yawa yana tare da pruritus, kuma ya kamata a yi la'akari da ƙara magungunan antipruritic.